BDBM50610167 CHEMBL5271038
SMILES Cc1cc(cnc1NC(=O)c2cc(c(cc2Cl)F)C(=O)NCc3ccc(c(c3)F)F)N4CCOCC4
InChI Key InChIKey=GBAXCPGBQNNUHB-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 10 hits for monomerid = 50610167
TargetPeroxisome proliferator-activated receptor gamma(Human)
Institute of Mit and Harvard
Curated by ChEMBL
Institute of Mit and Harvard
Curated by ChEMBL
Affinity DataEC50: 69nMAssay Description:Inverse agonist activity at GST tagged human PPARgamma LBD (231 to 505 residues) expressed in Escherichia coli BL21(DE3) assessed as recruitment of f...More data for this Ligand-Target Pair
3D Structure (crystal)TargetPeroxisome proliferator-activated receptor gamma(Human)
Institute of Mit and Harvard
Curated by ChEMBL
Institute of Mit and Harvard
Curated by ChEMBL
Affinity DataIC50: 8.30nMAssay Description:Inverse agonist activity at human PPARgamma in human RT112/84 transfected with NLuc-fused FABP4 assessed as reduction in PPARgamma transactivation in...More data for this Ligand-Target Pair
TargetNuclear receptor subfamily 1 group I member 2(Human)
Institute of Mit and Harvard
Curated by ChEMBL
Institute of Mit and Harvard
Curated by ChEMBL
Affinity DataIC50: 4.98E+4nMAssay Description:Transactivation of human PXR in human HepG2 cells co-expressing luciferase gene under control of CYP3A4 promoter assessed as increase in luciferase a...More data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Human)
Institute of Mit and Harvard
Curated by ChEMBL
Institute of Mit and Harvard
Curated by ChEMBL
Affinity DataIC50: 14nMAssay Description:Inverse agonist activity at human PPARgamma expressed in CHO cells co-expressing GAL4-NHR-LBD assessed as transcriptional repression preincubated for...More data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor alpha(Human)
Institute of Mit and Harvard
Curated by ChEMBL
Institute of Mit and Harvard
Curated by ChEMBL
Affinity DataIC50: 5.00E+3nMAssay Description:Agonist activity at human PPARalpha expressed in CHO cells co-expressing GAL4-NHR-LBD assessed as transcriptional activation preincubated for 6 hrs f...More data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor delta(Human)
Institute of Mit and Harvard
Curated by ChEMBL
Institute of Mit and Harvard
Curated by ChEMBL
Affinity DataIC50: 5.00E+3nMAssay Description:Inverse agonist activity at human PPARdelta expressed in CHO cells co-expressing GAL4-NHR-LBD assessed as transcriptional repression preincubated for...More data for this Ligand-Target Pair
Affinity DataIC50: 5.00E+3nMAssay Description:Inverse agonist activity at human FXR expressed in CHO cells co-expressing GAL4-NHR-LBD assessed as transcriptional repression preincubated for 6 hrs...More data for this Ligand-Target Pair
Affinity DataIC50: 5.00E+3nMAssay Description:Inverse agonist activity at human THRA expressed in CHO cells co-expressing GAL4-NHR-LBD assessed as transcriptional repression preincubated for 6 hr...More data for this Ligand-Target Pair
Affinity DataIC50: 5.00E+3nMAssay Description:Inverse agonist activity at human THRB expressed in CHO cells co-expressing GAL4-NHR-LBD assessed as transcriptional repression preincubated for 6 hr...More data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Mouse)
Institute of Mit and Harvard
Curated by ChEMBL
Institute of Mit and Harvard
Curated by ChEMBL
Affinity DataIC50: 24nMAssay Description:Inverse agonist activity at PPARgamma in mouse 3T3-L1 adipocytes assessed as inhibition of adipogenesis by measuring lipid droplet staining by BODIPY...More data for this Ligand-Target Pair