BDBM50609739 CHEMBL5266616

SMILES CC(C)(O)C12CC(C1)N(C2)c1cc(ncn1)-n1ncc2ccc(cc12)C1(CC1(C)C)C#N

InChI Key InChIKey=BFNGUPWVPSHQGL-UHFFFAOYSA-N

Data  2 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50609739   

TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Merck

Curated by ChEMBL

LigandBDBM50609739(CHEMBL5266616)Copy SMILESCopy InChI

Affinity DataIC50: 35nMAssay Description:Inhibition of GST20-tagged human LRRK2 G2019S mutant using LRRKtide peptide preincubated for 15 mins followed by substrate addition and measured afte...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
4/20/2024
Entry Details
Copy Entry DOIPubMed
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TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Merck

Curated by ChEMBL

LigandBDBM50609739(CHEMBL5266616)Copy SMILESCopy InChI

Affinity DataIC50: 610nMAssay Description:Inhibition of GST20-tagged LRRK2 in human SH-SY5Y cells assessed as reduction in pSer935 phosphorylation incubated for 90 mins by MSD assayMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
4/20/2024
Entry Details
Copy Entry DOIPubMed
Copy Rxn URL