BDBM50609519 CHEMBL5266172

SMILES CC(C)c1nn(c(C)c1-c1c(C)ccc2[nH]ncc12)-c1ccc(NC(=O)C=C)cc1F

InChI Key InChIKey=DKNNJRNFDCLOQZ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50609519   

TargetGTPase KRas(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50609519(CHEMBL5266172)
Affinity DataIC50: 500nMAssay Description:Inhibition of KRAS G12C mutant in human NCI-H358 cells assessed as reduction in ERK phosphorylation incubated for 6 hrs by MSD assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed