BDBM50609440 CHEMBL5271682

SMILES COc1cc(ccc1Nc1ncc(Cl)c(Nc2ccc3COB(O)c3c2)n1)N1CCC(CC1)N(C)C

InChI Key InChIKey=NXBFYHJMYLEINJ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50609440   

TargetALK tyrosine kinase receptor(Human)
Nanjing University

Curated by ChEMBL
LigandPNGBDBM50609440(CHEMBL5271682)
Affinity DataIC50: 11nMAssay Description:Inhibition of N-terminal GST-tagged human wild type ALK cytoplasmic domain (1058 to 1620 residues) expressed in baculovirus-infected Sf21 cells using...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetALK tyrosine kinase receptor(Human)
Nanjing University

Curated by ChEMBL
LigandPNGBDBM50609440(CHEMBL5271682)
Affinity DataIC50: 22nMAssay Description:Inhibition of N-terminal GST-tagged human ALK cytoplasmic domain (1058 to 1620 residues) C1156Y mutant expressed in baculovirus-infected Sf21 cells u...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetALK tyrosine kinase receptor(Human)
Nanjing University

Curated by ChEMBL
LigandPNGBDBM50609440(CHEMBL5271682)
Affinity DataIC50: 8.40nMAssay Description:Inhibition of N-terminal GST-tagged human ALK cytoplasmic domain (1058 to 1620 residues) L1196M mutant expressed in baculovirus-infected Sf21 cells u...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed