BDBM50609427 CHEMBL5289464

SMILES CCN(C1CCOCC1)c1cc(cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C)-c1ccc(CN2CCN(CC2)C(=O)CCCCCCCC(=O)N[C@H](C(=O)N2C[C@H](O)C[C@H]2C(=O)NCc2ccc(cc2)-c2scnc2C)C(C)(C)C)cc1

InChI Key InChIKey=AOIZISCRIVNZJJ-UHFFFAOYSA-N

Data  1 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50609427   

TargetHistone-lysine N-methyltransferase EZH2(Human)
Second Military Medical University (Naval Medical University)

Curated by ChEMBL
LigandPNGBDBM50609427(CHEMBL5289464)
Affinity DataEC50:  140nMAssay Description:Induction of degradation of EZH2 degradation in human MDA-MB-453 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase EZH2(Human)
Second Military Medical University (Naval Medical University)

Curated by ChEMBL
LigandPNGBDBM50609427(CHEMBL5289464)
Affinity DataIC50: 8.60E+3nMAssay Description:Inhibition of EZH2 (unknown origin) using plate-coated histone as substrate at 5 uM incubated for 90 mins in presence of 5 uM SAM by AlphaScreen assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed