BDBM50607924 CHEMBL5278864

SMILES NC(=O)C(=C/c1cccc(c1)-c1ncnc2[nH]ccc12)\C#N

InChI Key InChIKey=PBACTZXZNFJQGT-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50607924   

TargetRibosomal protein S6 kinase alpha-3(Human)
Research Centre For Natural Sciences

Curated by ChEMBL
LigandPNGBDBM50607924(CHEMBL5278864)
Affinity DataIC50: 399nMAssay Description:Inhibition of RSK2 (unknown origin) at 100 uM preincubated for 1 hr followed by substrate addition and measured after 1 hr by Z-lyte assay relative t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 4(Human)
Research Centre For Natural Sciences

Curated by ChEMBL
LigandPNGBDBM50607924(CHEMBL5278864)
Affinity DataIC50: 281nMAssay Description:Inhibition of MAP2K4 (unknown origin) at 100 uM preincubated for 1 hr followed by substrate addition and measured after 1 hr by Z-lyte assay relative...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Research Centre For Natural Sciences

Curated by ChEMBL
LigandPNGBDBM50607924(CHEMBL5278864)
Affinity DataIC50: 56nMAssay Description:Inhibition of JAK3 (unknown origin) incubated for 45 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Research Centre For Natural Sciences

Curated by ChEMBL
LigandPNGBDBM50607924(CHEMBL5278864)
Affinity DataIC50: 0.770nMAssay Description:Inhibition of JAK3 (unknown origin) incubated for 45 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Research Centre For Natural Sciences

Curated by ChEMBL
LigandPNGBDBM50607924(CHEMBL5278864)
Affinity DataIC50: 0.770nMAssay Description:Inhibition of JAK3 (unknown origin) preincubated for 1 hr followed by substrate addition and measured after 1 hr by Z-lyte assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetMaternal embryonic leucine zipper kinase(Human)
Research Centre For Natural Sciences

Curated by ChEMBL
LigandPNGBDBM50607924(CHEMBL5278864)
Affinity DataIC50: 26nMAssay Description:Inhibition of MELK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed