BDBM50606734 CHEMBL5221072

SMILES CCC1(C)CN(c2c1ncnc2N)c1ccc2oc(N)nc2c1

InChI Key InChIKey=CEPOCJCCKQHPAE-UHFFFAOYSA-N

Data  1 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50606734   

TargetTarget of rapamycin complex subunit LST8(Human)
University of Hradec Kralove

Curated by ChEMBL
LigandPNGBDBM50606734(CHEMBL5221072)
Affinity DataIC50: 8.60nMAssay Description:Inhibition of mTORC1 in human A-431 cells assessed as phosphorylated S6RP level incubated for 3 hrs by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetTarget of rapamycin complex 2 subunit MAPKAP1(Human)
University of Hradec Kralove

Curated by ChEMBL
LigandPNGBDBM50606734(CHEMBL5221072)
Affinity DataIC50: 16nMAssay Description:Inhibition of mTORC2 in human A-431 cells assessed as phosphorylated AKT level incubated for 3 hrs by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
University of Hradec Kralove

Curated by ChEMBL
LigandPNGBDBM50606734(CHEMBL5221072)
Affinity DataKi:  35nMAssay Description:Binding affinity to mTOR (unknown origin) assessed as inhibition constant measured after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed