BDBM50606397 CHEMBL5169565

SMILES CC(C)C[C@H](NC(=O)[C@H](CCN)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)CCCCNC(=O)c1ccc(Oc2ccc(cc2)C(N)=O)cc1)C(=O)N(C)[C@@H](CCC(O)=O)C(=O)N1CCC[C@H]1CC(N)=O

InChI Key InChIKey=FVDPKGPPYGTKTO-UHFFFAOYSA-N

Data  1 KI  15 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 16 hits for monomerid = 50606397   

Target72 kDa type IV collagenase(Human)
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50606397(CHEMBL5169565)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of recombinant human MMP2 using MOCAc-Lys-Pro-Leu-Gly-Leu-A2pr(Dnp)-Ala-Arg-NH2 as a substrate preincubated for 15 mins followed by substr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetMacrophage metalloelastase(Human)
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50606397(CHEMBL5169565)
Affinity DataIC50: 1.37E+3nMAssay Description:Inhibition of recombinant human MMP12 using MOCAc-Pro-Leu-Gly-Leu-A2pr(Dnp)-Ala-Arg-NH2 as substrate preincubated for 15 mins followed by substrate a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetCollagenase 3(Human)
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50606397(CHEMBL5169565)
Affinity DataIC50: 174nMAssay Description:Inhibition of recombinant human MMP13 using MOCAc-Pro-Leu-Gly-Leu-A2pr(Dnp)-Ala-Arg-NH2 as substrate preincubated for 15 mins followed by substrate a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetInterstitial collagenase(Human)
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50606397(CHEMBL5169565)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant human MMP1 using MOCAc-Lys-Pro-Leu-Gly-Leu-A2pr(Dnp)-Ala-Arg-NH2 as substrate preincubated for 15 mins followed by substrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetStromelysin-1(Human)
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50606397(CHEMBL5169565)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant human MMP3 using MOCAc-Lys-Pro-Leu-Gly-Leu-A2pr(Dnp)-Ala-Arg-N2 as substrate preincubated for 15 mins followed by substrate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetMatrilysin(Human)
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50606397(CHEMBL5169565)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant human MMP7 using MOCAc-Pro-Leu-Gly-Leu-A2pr(Dnp)-Ala-Arg-NH2 as substrate preincubated for 15 mins followed by substrate ad...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetNeutrophil collagenase(Human)
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50606397(CHEMBL5169565)
Affinity DataIC50: 3.73E+3nMAssay Description:Inhibition of recombinant human MMP8 using MOCAc-Pro-Leu-Gly-Leu-A2pr(Dnp)-Ala-Arg-NH2 as substrate preincubated for 15 mins followed by substrate ad...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetMatrix metalloproteinase-9(Human)
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50606397(CHEMBL5169565)
Affinity DataIC50: 8.51E+3nMAssay Description:Inhibition of recombinant human MMP9 using MOCAc-Pro-Leu-Gly-Leu-A2pr(Dnp)-Ala-Arg-NH2 as substrate preincubated for 15 mins followed by substrate ad...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetMatrix metalloproteinase-14(Human)
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50606397(CHEMBL5169565)
Affinity DataIC50: 2.22E+3nMAssay Description:Inhibition of recombinant human MMP14 using MOCAc-Lys-Pro-Leu-Gly-Leu-A2pr(Dnp)-Ala-Arg-NH2 as substrate preincubated for 15 mins followed by substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50606397(CHEMBL5169565)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human ERG expressed in CHO cells by Qpatch-clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
Target72 kDa type IV collagenase(Human)
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50606397(CHEMBL5169565)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of MMP2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetMacrophage metalloelastase(Human)
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50606397(CHEMBL5169565)
Affinity DataIC50: 1.37E+3nMAssay Description:Inhibition of human recombinant MMP12 using MOCAc-Lys-Pro-Leu-Gly-Leu-A2pr(Dnp)-Ala-Arg-N2 as substrate preincubated for 10 to 15 mins followed by su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetCollagenase 3(Human)
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50606397(CHEMBL5169565)
Affinity DataIC50: 174nMAssay Description:Inhibition of human recombinant MMP13 using MOCAc-Lys-Pro-Leu-Gly-Leu-A2pr(Dnp)-Ala-Arg-N2 as substrate preincubated for 10 to 15 mins followed by su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
Target72 kDa type IV collagenase(Human)
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50606397(CHEMBL5169565)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of human recombinant MMP2 using MOCAc-Lys-Pro-Leu-Gly-Leu-A2pr(Dnp)-Ala-Arg-N2 as substrate preincubated for 15 mins followed by substrate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
Target72 kDa type IV collagenase(Human)
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50606397(CHEMBL5169565)
Affinity DataIC50: 0.290nMAssay Description:Inhibition of human recombinant MMP2 using MOCAc-Lys-Pro-Leu-Gly-Leu-A2pr(Dnp)-Ala-Arg-N2 as substrate preincubated for 5 mins followed by substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
Target72 kDa type IV collagenase(Human)
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50606397(CHEMBL5169565)
Affinity DataKi:  0.180nMAssay Description:Inhibition of recombinant human MMP2 using MOCAc-Lys-Pro-Leu-Gly-Leu-A2pr(Dnp)-Ala-Arg-N2 as substrate preincubated for 10 to 15 mins followed by sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed