BDBM50606100 CHEMBL5173004

SMILES C[C@H](Oc1ccc(cc1)-c1cc2c(ncnc2[nH]1)C1=CCNCC1)c1ccccc1

InChI Key InChIKey=VLMCQFYFLOLDQX-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50606100   

TargetProtein arginine N-methyltransferase 1(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50606100(CHEMBL5173004)
Affinity DataIC50: 3.25E+3nMAssay Description:Inhibition of PRMT1 (unknown origin) using histone H4 (1 to 21 residues) peptide as substrate incubated for 210 mins in presence of SAM by AlphaLISA ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase EZH2(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50606100(CHEMBL5173004)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of EZH2 (unknown origin) using peptide substrate preincubated for 10 mins followed by substrate addition for 4 hrs by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase 2A(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50606100(CHEMBL5173004)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of MLL1 (unknown origin) using peptide substrate preincubated for 10 mins followed by substrate addition for 4 hrs by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase 2B(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50606100(CHEMBL5173004)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of MLL4 (unknown origin) using peptide substrate preincubated for 10 mins followed by substrate addition for 4 hrs by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetProtein arginine N-methyltransferase 5(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50606100(CHEMBL5173004)
Affinity DataIC50: 47nMAssay Description:Inhibition of PRMT5 (unknown origin) using histone H4 (1 to 21 residues) peptide/SAM as substrate incubated for 210 mins in presence of SAM by AlphaL...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase NSD2(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50606100(CHEMBL5173004)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of NSD2 (unknown origin) using histone H4 (1 to 21 residues) peptide/SAM as substrate incubated for 210 mins in presence of SAM by AlphaLI...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetHistone-arginine methyltransferase CARM1(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50606100(CHEMBL5173004)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of PRMT4 (unknown origin) using histone H4 (1 to 21 residues) peptide/SAM as substrate incubated for 210 mins in presence of SAM by AlphaL...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetProtein arginine N-methyltransferase 5(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50606100(CHEMBL5173004)
Affinity DataIC50: 24nMAssay Description:Displacement of [3H]-SAM from PRMT5 (unknown origin) using peptide substrate preincubated for 15 mins followed by substrate addition for 60 mins by r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed