BDBM50605977 CHEMBL5191002

SMILES O=S(=O)(N1CCNCC1)c1ccc(NC(=S)NCc2cccnc2)cc1

InChI Key InChIKey=UMAXVLXCXUDIDV-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50605977   

TargetNicotinamide phosphoribosyltransferase(Human)
Second Military Medical University

Curated by ChEMBL
LigandPNGBDBM50605977(CHEMBL5191002)
Affinity DataIC50: 85nMAssay Description:Inhibition of human recombinant NAMPT preincubated for 5 mins followed by addition NAMPT measured after 15 mins by HTS assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetNicotinamide phosphoribosyltransferase(Human)
Second Military Medical University

Curated by ChEMBL
LigandPNGBDBM50605977(CHEMBL5191002)
Affinity DataIC50: 85nMAssay Description:Inhibition of NAMPT (unknown origin) measured after 90 mins by measuring fluorescence intensityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetNicotinamide phosphoribosyltransferase(Human)
Second Military Medical University

Curated by ChEMBL
LigandPNGBDBM50605977(CHEMBL5191002)
Affinity DataIC50: 85nMAssay Description:Inhibition of NAMPT (unknown origin) using PRPP as substrates incubated in presence of ATP by fluorimetric plate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetNicotinamide phosphoribosyltransferase(Human)
Second Military Medical University

Curated by ChEMBL
LigandPNGBDBM50605977(CHEMBL5191002)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of NAMPT in human A2780 cells measured at 6 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetNicotinamide phosphoribosyltransferase(Human)
Second Military Medical University

Curated by ChEMBL
LigandPNGBDBM50605977(CHEMBL5191002)
Affinity DataIC50: 7.18E+3nMAssay Description:Inhibition of NAMPT in human A2780 cells measured at 24 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetNicotinamide phosphoribosyltransferase(Human)
Second Military Medical University

Curated by ChEMBL
LigandPNGBDBM50605977(CHEMBL5191002)
Affinity DataIC50: 4.05E+3nMAssay Description:Inhibition of NAMPT in human A2780 cells measured at 48 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed