BDBM50605888 CHEMBL5179759

SMILES Cc1onc(c1COc1ccc2CN(CCc2n1)C(=O)C1CCS(=O)(=O)CC1)-c1ccc(F)cc1

InChI Key InChIKey=DDRXKTPRVSLWJP-UHFFFAOYSA-N

Data  1 KI  1 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50605888   

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Gedeon Richter

Curated by ChEMBL

LigandBDBM50605888(CHEMBL5179759)Copy SMILESCopy InChI

Affinity DataIC50: 2.90E+3nMAssay Description:Inhibition of hERG expressed in CHO cells stably at -80 mV holding potential by automated patch clamp methodMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProtUniProtKB/TrEMBL
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
6/25/2023
Entry Details
Copy Entry DOIPubMed
Copy Rxn URL

TargetGABA-A receptor; alpha-5/beta-3/gamma-2(Human)
Gedeon Richter

Curated by ChEMBL

LigandBDBM50605888(CHEMBL5179759)Copy SMILESCopy InChI

Affinity DataKi:  3.60nMAssay Description:Displacement of [3H]Ro151788 from human recombinant alpha5beta3gamma2 GABAA receptor stably expressed in HEK293 cell membrane assessed as inhibition ...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
6/25/2023
Entry Details
Copy Entry DOIPubMed
Copy Rxn URL