BDBM50604700 CHEMBL5191391

SMILES COc1cc(Oc2c(sc3c2ccc2[nH]ncc32)-c2ccc(F)cc2CC(F)(F)F)ccc1NC1CN(CCCF)C1

InChI Key InChIKey=JJPMYVJPFFROOP-UHFFFAOYSA-N

Data  1 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50604700   

TargetEstrogen receptor(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50604700(CHEMBL5191391)
Affinity DataEC50:  2.20nMAssay Description:Induction of ERalpha degradation in human MCF7 cells incubated for 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetEstrogen receptor(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50604700(CHEMBL5191391)
Affinity DataIC50: 1.10nMAssay Description:Antagonist activity at ERalpha expressed in HEK293/Gal4 cells incubated for 24 hrs in presence of estradiol by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed