BDBM50604105 CHEMBL5208454

SMILES ClCCC(=O)Nc1ccc2ncnc(Nc3ccc4[nH]cc(Br)c4c3)c2c1

InChI Key InChIKey=WTWFBKFNVCFROY-UHFFFAOYSA-N

Data  15 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 18 hits for monomerid = 50604105   

TargetEpidermal growth factor receptor(Human)
Affiliated Cancer Hospital of University of Electronic Science and Technology of China

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50604105BDBM50604105(CHEMBL5208454)
Affinity DataIC50: 0.720nMAssay Description:Inhibition of 1,10-phenanthrolin-induced HIF1 activation in human T47D cells expressing pGL3 construct after 16 hrs by cell-based luciferase reporter...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2026
Entry Details PubMed
TargetEpidermal growth factor receptor(Human)
Affiliated Cancer Hospital of University of Electronic Science and Technology of China

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50604105BDBM50604105(CHEMBL5208454)
Affinity DataIC50: 0.720nMAssay Description:Inhibition of wild-type EGFR (14 to 721 residues) (unknown origin) by western blot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetReceptor tyrosine-protein kinase erbB-4(Human)
Wenzhou Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50604105BDBM50604105(CHEMBL5208454)
Affinity DataIC50: 2nMAssay Description:Inhibition of HER4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Affiliated Cancer Hospital of University of Electronic Science and Technology of China

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50604105BDBM50604105(CHEMBL5208454)
Affinity DataIC50: 8.20nMAssay Description:Inhibition of 1,10-phenanthrolin-induced HIF1 activation in human T47D cells expressing pGL3 construct after 16 hrs by cell-based luciferase reporter...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2026
Entry Details PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Affiliated Cancer Hospital of University of Electronic Science and Technology of China

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50604105BDBM50604105(CHEMBL5208454)
Affinity DataIC50: 75nMAssay Description:Inhibition of gamma-secretase mediated amyloid beta-40 production in HEK293 cells by whole cell-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2026
Entry Details PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Affiliated Cancer Hospital of University of Electronic Science and Technology of China

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50604105BDBM50604105(CHEMBL5208454)
Affinity DataIC50: 75nMAssay Description:Inhibition of HER2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Affiliated Cancer Hospital of University of Electronic Science and Technology of China

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50604105BDBM50604105(CHEMBL5208454)
Affinity DataIC50: 82nMAssay Description:Inhibition of recombinant human EGFR L858R/T790M double mutant using GGMEDIYFEFMGG as substrate in presence of ATP by radiometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Wenzhou Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50604105BDBM50604105(CHEMBL5208454)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of SRC (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Wenzhou Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50604105BDBM50604105(CHEMBL5208454)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of IGF1R (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetTyrosine-protein kinase ABL1(Human)
Wenzhou Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50604105BDBM50604105(CHEMBL5208454)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of ABL (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
Wenzhou Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50604105BDBM50604105(CHEMBL5208454)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PDGFR-beta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetFibroblast growth factor receptor 1(Human)
Wenzhou Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50604105BDBM50604105(CHEMBL5208454)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of FGFR1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetVascular endothelial growth factor receptor 1(Human)
Wenzhou Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50604105BDBM50604105(CHEMBL5208454)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Flt-1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
Wenzhou Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50604105BDBM50604105(CHEMBL5208454)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of c-Kit (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha(Human)
Wenzhou Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50604105BDBM50604105(CHEMBL5208454)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PDGFR-alpha (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Wenzhou Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50604105BDBM50604105(CHEMBL5208454)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of VEGFR2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetEphrin type-A receptor 2(Human)
Wenzhou Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50604105BDBM50604105(CHEMBL5208454)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of EPH-A2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Wenzhou Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50604105BDBM50604105(CHEMBL5208454)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of RET (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed