BDBM50602927 CHEMBL5193908::US20250051335, Compound 25

SMILES O=C(c1ccccc1)c1ccc(Nc2ncnc3[nH]ccc23)cc1

InChI Key InChIKey=XGGPMDVLGJQXOK-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50602927   

TargetTau-tubulin kinase 1(Human)
Csic

Curated by ChEMBL
LigandPNGBDBM50602927(CHEMBL5193908 | US20250051335, Compound 25)
Affinity DataIC50: 1.71E+3nMAssay Description:Inhibition of recombinant human TTBK1 using RICDLHDDEEDEAMSITA as substrate incubated for 30 mins in presence of 33P-gamma-ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetTau-tubulin kinase 2(Human)
Csic

Curated by ChEMBL
LigandPNGBDBM50602927(CHEMBL5193908 | US20250051335, Compound 25)
Affinity DataIC50: 1.19E+4nMAssay Description:Inhibition of recombinant human TTBK2 using RICDLHDDEEDEAMSITA as substrate incubated for 30 mins in presence of 33P-gamma-ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetTau-tubulin kinase 1(Human)
Csic

Curated by ChEMBL
LigandPNGBDBM50602927(CHEMBL5193908 | US20250051335, Compound 25)
Affinity DataIC50: 1.71E+3nMAssay Description:A buffer solution containing the recombinant human enzyme TTBK1 (1-1321) or TTBK2(1-450) (5-20 mU) and 50 mM Tris at pH 7.5, 0.1 mM EGTA, 0.1% p-merc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/17/2025
Entry Details
Go to US Patent

TargetTau-tubulin kinase 2 [1-450](Human)
Csic

US Patent
LigandPNGBDBM50602927(CHEMBL5193908 | US20250051335, Compound 25)
Affinity DataIC50: 1.19E+4nMAssay Description:A buffer solution containing the recombinant human enzyme TTBK1 (1-1321) or TTBK2(1-450) (5-20 mU) and 50 mM Tris at pH 7.5, 0.1 mM EGTA, 0.1% p-merc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/17/2025
Entry Details
Go to US Patent