BDBM50602926 CHEMBL5200160::US11814388, Compound 9::US20250051335, Compound 24

SMILES C(Oc1ccc(Nc2ncnc3[nH]ccc23)cc1)c1ccccc1

InChI Key InChIKey=GSVSRJBZRJBGOQ-UHFFFAOYSA-N

Data  6 IC50  7 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50602926   

TargetEpidermal growth factor receptor(Human)
Ferris State University

US Patent
LigandPNGBDBM50602926(CHEMBL5200160 | US11814388, Compound 9 | US2025005...)
Affinity DataKd:  87nMAssay Description:Compounds 2-9 were evaluated in an ADP detection assay externally using the Kinomescan KdELECT platform from Discover X.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/8/2024
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor [L858R](Human)
Ferris State University

US Patent
LigandPNGBDBM50602926(CHEMBL5200160 | US11814388, Compound 9 | US2025005...)
Affinity DataKd:  680nMAssay Description:Compounds 2-9 were evaluated in an ADP detection assay externally using the Kinomescan KdELECT platform from Discover X.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/8/2024
Entry Details
Go to US Patent

TargetAurora kinase A(Human)
Ferris State University

US Patent
LigandPNGBDBM50602926(CHEMBL5200160 | US11814388, Compound 9 | US2025005...)
Affinity DataKd: >3.00E+4nMAssay Description:Compounds 2-9 were evaluated in an ADP detection assay externally using the Kinomescan KdELECT platform from Discover X.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/8/2024
Entry Details
Go to US Patent

TargetAurora kinase B(Human)
Ferris State University

US Patent
LigandPNGBDBM50602926(CHEMBL5200160 | US11814388, Compound 9 | US2025005...)
Affinity DataKd:  9.80E+3nMAssay Description:Compounds 2-9 were evaluated in an ADP detection assay externally using the Kinomescan KdELECT platform from Discover X.More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/8/2024
Entry Details
Go to US Patent

TargetTau-tubulin kinase 1(Human)
Csic

Curated by ChEMBL
LigandPNGBDBM50602926(CHEMBL5200160 | US11814388, Compound 9 | US2025005...)
Affinity DataIC50: 750nMAssay Description:Inhibition of recombinant human TTBK1 using RICDLHDDEEDEAMSITA as substrate incubated for 30 mins in presence of 33P-gamma-ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetTau-tubulin kinase 2(Human)
Csic

Curated by ChEMBL
LigandPNGBDBM50602926(CHEMBL5200160 | US11814388, Compound 9 | US2025005...)
Affinity DataIC50: 1.21E+3nMAssay Description:Inhibition of recombinant human TTBK2 using RICDLHDDEEDEAMSITA as substrate incubated for 30 mins in presence of 33P-gamma-ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetTau-tubulin kinase 1(Human)
Csic

Curated by ChEMBL
LigandPNGBDBM50602926(CHEMBL5200160 | US11814388, Compound 9 | US2025005...)
Affinity DataIC50: 750nMAssay Description:A buffer solution containing the recombinant human enzyme TTBK1 (1-1321) or TTBK2(1-450) (5-20 mU) and 50 mM Tris at pH 7.5, 0.1 mM EGTA, 0.1% p-merc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/17/2025
Entry Details
Go to US Patent

TargetTau-tubulin kinase 2 [1-450](Human)
Csic

US Patent
LigandPNGBDBM50602926(CHEMBL5200160 | US11814388, Compound 9 | US2025005...)
Affinity DataIC50: 1.21E+3nMAssay Description:A buffer solution containing the recombinant human enzyme TTBK1 (1-1321) or TTBK2(1-450) (5-20 mU) and 50 mM Tris at pH 7.5, 0.1 mM EGTA, 0.1% p-merc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/17/2025
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor(Human)
Ferris State University

US Patent
LigandPNGBDBM50602926(CHEMBL5200160 | US11814388, Compound 9 | US2025005...)
Affinity DataKd:  87nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Ferris State University

US Patent
LigandPNGBDBM50602926(CHEMBL5200160 | US11814388, Compound 9 | US2025005...)
Affinity DataKd:  680nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetAurora kinase B(Human)
Ferris State University

US Patent
LigandPNGBDBM50602926(CHEMBL5200160 | US11814388, Compound 9 | US2025005...)
Affinity DataKd:  9.80E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Ferris State University

US Patent
LigandPNGBDBM50602926(CHEMBL5200160 | US11814388, Compound 9 | US2025005...)
Affinity DataIC50: 4.70E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Ferris State University

US Patent
LigandPNGBDBM50602926(CHEMBL5200160 | US11814388, Compound 9 | US2025005...)
Affinity DataIC50: 4.56E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed