BDBM50602904 CHEMBL5204869::US20250051335, Compound 2

SMILES c1cc(ccc1Nc2c3cc[nH]c3ncn2)Oc4ccc(cc4)Cl

InChI Key InChIKey=RWRSKMSFZCQDMQ-UHFFFAOYSA-N

Data  4 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50602904   

TargetTau-tubulin kinase 1(Human)
Csic

Curated by ChEMBL
LigandPNGBDBM50602904(CHEMBL5204869 | US20250051335, Compound 2)
Affinity DataIC50: 240nMAssay Description:Inhibition of recombinant human TTBK1 using RICDLHDDEEDEAMSITA as substrate incubated for 30 mins in presence of 33P-gamma-ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetTau-tubulin kinase 2(Human)
Csic

Curated by ChEMBL
LigandPNGBDBM50602904(CHEMBL5204869 | US20250051335, Compound 2)
Affinity DataIC50: 4.22E+3nMAssay Description:Inhibition of recombinant human TTBK2 using RICDLHDDEEDEAMSITA as substrate incubated for 30 mins in presence of 33P-gamma-ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetTau-tubulin kinase 1(Human)
Csic

Curated by ChEMBL
LigandPNGBDBM50602904(CHEMBL5204869 | US20250051335, Compound 2)
Affinity DataIC50: 240nMAssay Description:A buffer solution containing the recombinant human enzyme TTBK1 (1-1321) or TTBK2(1-450) (5-20 mU) and 50 mM Tris at pH 7.5, 0.1 mM EGTA, 0.1% p-merc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/17/2025
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)
TargetTau-tubulin kinase 2 [1-450](Human)
Csic

US Patent
LigandPNGBDBM50602904(CHEMBL5204869 | US20250051335, Compound 2)
Affinity DataIC50: 4.22E+3nMAssay Description:A buffer solution containing the recombinant human enzyme TTBK1 (1-1321) or TTBK2(1-450) (5-20 mU) and 50 mM Tris at pH 7.5, 0.1 mM EGTA, 0.1% p-merc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/17/2025
Entry Details
Go to US Patent