BDBM50602851 CHEMBL5189539

SMILES Nc1nccc(n1)-c1sc(nc1-c1cccc(NS(=O)(=O)c2cc(F)ccc2F)c1F)C1CCCN1

InChI Key InChIKey=YFTCMSQTEOCRBN-UHFFFAOYSA-N

Data  1 IC50  1 EC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50602851   

TargetSerine/threonine-protein kinase B-raf(Human)
Cnrs

Curated by ChEMBL

LigandBDBM50602851(CHEMBL5189539)Copy SMILESCopy InChI

Affinity DataIC50: 1.70nMAssay Description:Inhibition of N-terminal His-tagged human recombinant B-Raf V600E mutant (448 to 723 residues) expressed in Escherichia coli BL21 (DE3) by Lanthascre...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
6/24/2023
Entry Details
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TargetNuclear receptor subfamily 1 group I member 2(Human)
Cnrs

Curated by ChEMBL

LigandBDBM50602851(CHEMBL5189539)Copy SMILESCopy InChI

Affinity DataEC50:  9.79E+3nMAssay Description:Transactivation of Gal4-tagged human PXR transfected in human HeLa cells preincubated for 16 hrs followed by luciferin addition and measured after 10...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
6/24/2023
Entry Details
Copy Entry DOIPubMed
Copy Rxn URL