BDBM506026 6-(((SMM[1,1'-bi(cyclopropan)]- 1-yl)-1H-1,2,3- triazol-4-yl)(6-fluoro-2-methylpyridin-3- yl)methyl)amino)-4-(((R)-3,3- dimethyltetrahydro- 2H-pyran-4-yl)amino)quinoline- 3,8-dicarbonitrile::US11066414, Compound 675

SMILES Cc1nc(F)ccc1[C@H](Nc1cc(C#N)c2ncc(C#N)c(NC3CCOCC3(C)C)c2c1)C1=CN(NN1)C1(CC1)C1CC1

InChI Key InChIKey=QJKNGVWVZLTPDY-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 506026   

TargetEpidermal growth factor receptor(Human)
Gilead Sciences

US Patent
LigandPNGBDBM506026(6-(((SMM[1,1'-bi(cyclopropan)]- 1-yl)-1H-1,2,3- tr...)
Affinity DataIC50: 1nMAssay Description:EGFR activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, EGFR-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2021
Entry Details
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