BDBM50602555 CHEMBL5194771::US11963959, Compound 8

SMILES c1ccc(c(c1)Cn2ccc3c2ccc4c3c(nc(n4)N)N)F

InChI Key InChIKey=HAPAUTSWUJUYGK-UHFFFAOYSA-N

Data  1 IC50  1 EC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50602555   

TargetThymidylate synthase(Escherichia coli (strain K12))
Peking Union Medical College

Curated by ChEMBL
LigandPNGBDBM50602555(CHEMBL5194771 | US11963959, Compound 8)
Affinity DataIC50: 1.12E+4nMAssay Description:Inhibition of Escherichia coli N-terminal hexahstidine-tagged TS by steady-state kinetic analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Southwest Research Institute

US Patent
LigandPNGBDBM50602555(CHEMBL5194771 | US11963959, Compound 8)
Affinity DataEC50:  50nMAssay Description:To determine potency and selectivity index of identified hits, compounds were tested in 8-point dose response with a 3-fold step dilution at concentr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/12/2024
Entry Details
Go to US Patent