BDBM50602543 CHEMBL4598338

SMILES COC1=CC(=O)N([C@H]1Cc1c[nH]c2ccccc12)C(=O)\C=C\[C@H](C)NC(=O)[C@H](CCc1ccccc1)NC(=O)[C@H](CC1CCCCC1)NC(=O)[C@H](C(C)C)N(C)C

InChI Key InChIKey=OKCRMEZBXWRMEQ-UHFFFAOYSA-N

Data  3 KI  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50602543   

TargetProcathepsin L(Human)
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM50602543(CHEMBL4598338)
Affinity DataIC50: 0.00600nMAssay Description:Inhibition of human recombinant Cathepsin L assessed remaining activity using Z-FR-AMC as substrate incubated for 30 mins by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetCathepsin B(Human)
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM50602543(CHEMBL4598338)
Affinity DataIC50: 47.6nMAssay Description:Inhibition of human recombinant Cathepsin B assessed remaining activity using Z-FR-AMC as substrate incubated for 30 mins by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetCathepsin L2(Human)
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM50602543(CHEMBL4598338)
Affinity DataIC50: 186nMAssay Description:Inhibition of human recombinant Cathepsin V assessed remaining activity using Z-FR-AMC as substrate incubated for 30 mins by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetCruzipain(Trypanosoma cruzi)
University of California San Diego

Curated by ChEMBL
LigandPNGBDBM50602543(CHEMBL4598338)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of Trypanosoma cruzi cruzain using Z-FR-AMC as substrate preincubated for 10 mins followed by substrate addition by fluorimetric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2023
Entry Details
PubMed
TargetCathepsin S(Human)
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM50602543(CHEMBL4598338)
Affinity DataIC50: 60.3nMAssay Description:Inhibition of human recombinant Cathepsin S assessed remaining activity using Z-FR-AMC as substrate incubated for 30 mins by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetCathepsin K(Human)
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM50602543(CHEMBL4598338)
Affinity DataIC50: 219nMAssay Description:Inhibition of human recombinant Cathepsin K assessed remaining activity using Z-FR-AMC as substrate incubated for 30 mins by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetProcathepsin L(Human)
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM50602543(CHEMBL4598338)
Affinity DataKi:  3.10nMAssay Description:Inhibition of human recombinant Cathepsin L assessed as Apparent inhibition constant using Z-FR-AMC as substrate inubated for 30 mins by fluorometric...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetProcathepsin L(Mouse)
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM50602543(CHEMBL4598338)
Affinity DataKi:  16.5nMAssay Description:Inhibition of mouse Cathepsin L assessed as Apparent inhibition constant using Z-FR-AMC as substrate inubated for 30 mins by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetCathepsin B(Human)
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM50602543(CHEMBL4598338)
Affinity DataKi:  347nMAssay Description:Inhibition of human recombinant Cathepsin B assessed as Apparent inhibition constant using Z-FR-AMC as substrate inubated for 30 mins by fluorometric...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed