BDBM50602541 CHEMBL5209268

SMILES C[C@@H](C1CC1)N1Cc2cc(cc(OC(F)F)c2C1=O)-c1ccn2nc(N)c(C(=O)N[C@H]3CC[C@@](C)(O)CC3)c2n1

InChI Key InChIKey=OUMVIVLVCKGULO-UHFFFAOYSA-N

Data  1 KI  14 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 50602541   

LigandPNGBDBM50602541(CHEMBL5209268)
Affinity DataIC50: 34nMAssay Description:Inhibition of PI3Kgamma (unknown origin) in rhMPC1 stimulated human THP-1 cells assessed as reduction in Akt phosphorylation level at Ser473 residue ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
LigandPNGBDBM50602541(CHEMBL5209268)
Affinity DataIC50: 1.90nMAssay Description:Inhibition of PI3Kgamma (unknown origin) using PIP2 as substrate preincubated for 1 hr followed by substrate addition and measured after 60 mins in p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
LigandPNGBDBM50602541(CHEMBL5209268)
Affinity DataIC50: 300nMAssay Description:Inhibition of PI3Kgamma in SDF-1alpha stimulated human whole blood assessed as reduction in phospho-AKT kinase activity preincubated for 1 hr followe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
LigandPNGBDBM50602541(CHEMBL5209268)
Affinity DataIC50: 1.25E+3nMAssay Description:Inhibition of PI3Kalpha (unknown origin) using PIP2 as substrate preincubated for 1 hr followed by substrate addition and measured after 60 mins in p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
LigandPNGBDBM50602541(CHEMBL5209268)
Affinity DataIC50: 1.08E+3nMAssay Description:Inhibition of PI3Kdelta (unknown origin) using PIP2 as substrate preincubated for 1 hr followed by substrate addition and measured after 60 mins in p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
LigandPNGBDBM50602541(CHEMBL5209268)
Affinity DataIC50: 9.21E+3nMAssay Description:Inhibition of PI3Kbeta (unknown origin) using PIP2 as substrate preincubated for 1 hr followed by substrate addition and measured after 60 mins in pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetCytochrome P450 1A2(Human)
Arcus Biosciences

Curated by ChEMBL
LigandPNGBDBM50602541(CHEMBL5209268)
Affinity DataIC50: 2.00E+4nMAssay Description:Time dependent inhibition of CYP1A2 in human liver microsomes at 40 uM using phenacetin as substrate measured after 5 to 20 mins in presence of NADPH...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetCytochrome P450 2B6(Human)
Arcus Biosciences

Curated by ChEMBL
LigandPNGBDBM50602541(CHEMBL5209268)
Affinity DataIC50: 2.00E+4nMAssay Description:Time dependent inhibition of CYP2B6 in human liver microsomes at 40 uM measured after 5 to 20 mins in presence of NADPH by LC/MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetCytochrome P450 2C8(Human)
Arcus Biosciences

Curated by ChEMBL
LigandPNGBDBM50602541(CHEMBL5209268)
Affinity DataIC50: 2.00E+4nMAssay Description:Time dependent inhibition of CYP2C8 in human liver microsomes at 40 uM measured after 5 to 20 mins in presence of NADPH by LC/MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetCytochrome P450 2C9(Human)
Arcus Biosciences

Curated by ChEMBL
LigandPNGBDBM50602541(CHEMBL5209268)
Affinity DataIC50: 2.00E+4nMAssay Description:Time dependent inhibition of CYP2C9 in human liver microsomes at 40 uM using diclofenac as substrate measured after 5 to 20 mins in presence of NADPH...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetCytochrome P450 2C19(Human)
Arcus Biosciences

Curated by ChEMBL
LigandPNGBDBM50602541(CHEMBL5209268)
Affinity DataIC50: 2.00E+4nMAssay Description:Time dependent inhibition of CYP2C19 in human liver microsomes at 40 uM using (S)-mephenytoin as substrate measured after 5 to 20 mins in presence of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetCytochrome P450 2D6(Human)
Arcus Biosciences

Curated by ChEMBL
LigandPNGBDBM50602541(CHEMBL5209268)
Affinity DataIC50: 2.00E+4nMAssay Description:Time dependent inhibition of CYP2D6 in human liver microsomes at 40 uM using dextromethorphan as substrate measured after 5 to 20 mins in presence of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetCytochrome P450 3A4(Human)
Arcus Biosciences

Curated by ChEMBL
LigandPNGBDBM50602541(CHEMBL5209268)
Affinity DataIC50: 2.00E+4nMAssay Description:Time dependent inhibition of CYP3A4 in human liver microsomes at 40 uM using midazolam as substrate measured after 5 to 20 mins in presence of NADPH ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Arcus Biosciences

Curated by ChEMBL
LigandPNGBDBM50602541(CHEMBL5209268)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human ERG by patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
LigandPNGBDBM50602541(CHEMBL5209268)
Affinity DataKi:  0.700nMAssay Description:Inhibition of PI3Kgamma (unknown origin) at 10 uM using PIP2 as substrate preincubated for 60 mins followed by substrate addition and measured after ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed