BDBM50602492 CHEMBL5202984

SMILES C[C@@H](C1CC1)N1Cc2cc(cc(C)c2C1=O)-c1ccn2nc(N)c(C(=O)Nc3cnn(C)c3)c2n1

InChI Key InChIKey=GAKYZOUCTWDUOZ-UHFFFAOYSA-N

Data  2 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50602492   

TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Human)
Arcus Biosciences

Curated by ChEMBL

LigandBDBM50602492(CHEMBL5202984)Copy SMILESCopy InChI

Affinity DataIC50: 127nMAssay Description:Inhibition of PI3Kgamma (unknown origin) in rhMPC1 stimulated human THP-1 cells assessed as reduction in Akt phosphorylation level at Ser473 residue ...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
6/24/2023
Entry Details
Copy Entry DOIPubMed
Copy Rxn URL

TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Human)
Arcus Biosciences

Curated by ChEMBL

LigandBDBM50602492(CHEMBL5202984)Copy SMILESCopy InChI

Affinity DataIC50: 3.40nMAssay Description:Inhibition of PI3Kgamma (unknown origin) using PIP2 as substrate preincubated for 1 hr followed by substrate addition and measured after 60 mins in p...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
6/24/2023
Entry Details
Copy Entry DOIPubMed
Copy Rxn URL