BDBM50602407 CHEMBL5206532

SMILES c1cc(sc1)CNC(=O)[C@@H]2CN(CCN2c3ccc(c(c3)Cl)Cl)C(=O)CCl

InChI Key InChIKey=DBKURSLDNAKNLU-UHFFFAOYSA-N

Data  7 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50602407   

TargetReplicase polyprotein 1ab(2019-nCoV)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50602407(CHEMBL5206532)
Affinity DataIC50: 180nMAssay Description:Inhibition of SARS-CoV-2 main protease using MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2 as substrate preincubated for 30 mins followed by substrate addition and m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetCathepsin B(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50602407(CHEMBL5206532)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human cathepsin B using Z-Leu-Arg-AMC as substrate by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetCathepsin F(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50602407(CHEMBL5206532)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human cathepsin F using Z-Phe-Arg-AMC as substrate by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetCathepsin K(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50602407(CHEMBL5206532)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human cathepsin K using Ac-LR-AFC as substrate by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetProcathepsin L(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50602407(CHEMBL5206532)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human cathepsin L using Z-Leu-Arg-AMC as substrate by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetCaspase-3(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50602407(CHEMBL5206532)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human caspase 3 using Ac-Asp-Glu-Val-Asp-pNA as substrate by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50602407(CHEMBL5206532)
Affinity DataIC50: 180nMAssay Description:Inhibition of recombinant N-terminal SARS-CoV-2 Main protease expressed in Escherichia coli using MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2 as substrate incubate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed