BDBM50602046 CHEMBL5178741::US20250034168, Compound 7

SMILES CCc1cc2ncc(CN3CCC(C3)Nc3ccc(nc3)C(=O)NC)cc2[nH]c1=O

InChI Key InChIKey=HBJRTNJBCUCSST-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50602046   

TargetPoly [ADP-ribose] polymerase 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50602046(CHEMBL5178741 | US20250034168, Compound 7)
Affinity DataIC50: 0.940nMAssay Description:Inhibition of PARP-1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetPoly [ADP-ribose] polymerase 2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50602046(CHEMBL5178741 | US20250034168, Compound 7)
Affinity DataIC50: 68nMAssay Description:Inhibition of PARP-2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50602046(CHEMBL5178741 | US20250034168, Compound 7)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of PARP-1 (unknown origin) binding to DNA assessed as DNA trapping activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetPoly [ADP-ribose] polymerase 2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50602046(CHEMBL5178741 | US20250034168, Compound 7)
Affinity DataIC50: 9.44E+3nMAssay Description:Inhibition of PARP-2 (unknown origin) binding to DNA assessed as DNA trapping activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50602046(CHEMBL5178741 | US20250034168, Compound 7)
Affinity DataIC50: 2.80nMAssay Description:PARP-1 chemical fluorescence detection kit was purchased from BPS Bioscience. The histone solution in the kit was diluted 5× with 1×PBS, and 25 μL of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2025
Entry Details
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