BDBM50601758 CHEMBL5170962::US11773078, Example 242

SMILES CS(=O)(=O)CCCN1CCN(CC1)c1ncc(Oc2cc(CN3CCC(CC(O)=O)CC3)cc(n2)-c2cc(Cl)cc(Cl)c2)cn1

InChI Key InChIKey=SNPSOUBNBXTISO-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50601758   

TargetFurin [108-574](Human)
Glaxosmithkline Intellectual Property Development

US Patent
LigandPNGBDBM50601758(CHEMBL5170962 | US11773078, Example 242)
Affinity DataIC50: 2.51nMAssay Description:Reactions were performed in black 384-well polystyrene low volume plates (Greiner). Furin (108-574-Tev-Flag-His) enzyme was expressed and purified fr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2023
Entry Details
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TargetFurin(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50601758(CHEMBL5170962 | US11773078, Example 242)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of Tev-FLAG-His-tagged furin (108 to 574 residues) (unknown origin) using FAM-QRVRRAVGIDK-TAMRA as substrate and measured after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed