BDBM50601748 CHEMBL5169887::US11773078, Example 12

SMILES CC(=O)NCC1CCN(Cc2cc(Oc3ccc(nc3)N3CCN(CCS(C)(=O)=O)CC3)nc(c2)-c2cc(Cl)cc(Cl)c2)CC1

InChI Key InChIKey=GQLFGFBRYFKBBJ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50601748   

TargetFurin [108-574](Human)
Glaxosmithkline Intellectual Property Development

US Patent
LigandPNGBDBM50601748(CHEMBL5169887 | US11773078, Example 12)
Affinity DataIC50: 5.01nMAssay Description:Reactions were performed in black 384-well polystyrene low volume plates (Greiner). Furin (108-574-Tev-Flag-His) enzyme was expressed and purified fr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2023
Entry Details
Go to US Patent

TargetFurin(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50601748(CHEMBL5169887 | US11773078, Example 12)
Affinity DataIC50: 5nMAssay Description:Inhibition of Tev-FLAG-His-tagged furin (108 to 574 residues) (unknown origin) using FAM-QRVRRAVGIDK-TAMRA as substrate and measured after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed