BDBM50601608 CHEMBL5209029

SMILES C[C@H]1CC[C@H](N1c1ncnc2[nH]cnc12)c1nc2cccc(Cl)c2c(=O)n1-c1cccc(F)c1

InChI Key InChIKey=VAZGOYCOZCCRPI-UHFFFAOYSA-N

Data  11 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50601608   

TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM50601608(CHEMBL5209029)
Affinity DataIC50: 14nMAssay Description:Inhibition of PI3Kdelta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Human)
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM50601608(CHEMBL5209029)
Affinity DataIC50: 267nMAssay Description:Inhibition of PI3Kgamma (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM50601608(CHEMBL5209029)
Affinity DataIC50: 4.43E+3nMAssay Description:Inhibition of PI3Kalpha (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Human)
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM50601608(CHEMBL5209029)
Affinity DataIC50: 375nMAssay Description:Inhibition of PI3Kbeta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM50601608(CHEMBL5209029)
Affinity DataIC50: 4.36E+3nMAssay Description:Inhibition of PI3Kalpha in human SK-OV-3 cells assessed as reduction in AKT phosphorylation at S473 residue incubated for 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Human)
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM50601608(CHEMBL5209029)
Affinity DataIC50: 943nMAssay Description:Inhibition of PI3Kbeta in human 786-0 cells assessed as reduction in AKT phosphorylation at S473 residue incubated for 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Mouse)
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM50601608(CHEMBL5209029)
Affinity DataIC50: 571nMAssay Description:Inhibition of PI3Kgamma in c5a-stimulated mouse RAW264.7 cells assessed as reduction in AKT phosphorylation at S473 residue incubated for 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM50601608(CHEMBL5209029)
Affinity DataIC50: 25nMAssay Description:Inhibition of PI3Kdelta in anti-IgM-stimulated human Raji cells assessed as reduction in AKT phosphorylation at S473 residue incubated for 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM50601608(CHEMBL5209029)
Affinity DataIC50: 8.20nMAssay Description:Inhibition of PI3Kdelta in anti-FceRI-stimulated human Basophil cells degranulation incubated for 30 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM50601608(CHEMBL5209029)
Affinity DataIC50: 100nMAssay Description:Inhibition of PI3Kdelta in anti-IgM-stimulated human whole blood B cell degranulation incubated for 60 mins by flow cytometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM50601608(CHEMBL5209029)
Affinity DataIC50: 21nMAssay Description:Inhibition of PI3Kdelta in conA-stimulated primary human T cell proliferation incubated for 1 hr by CellTiter-glo luminescent assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed