BDBM50601246 CHEMBL5185500

SMILES S=c1cc(CC2CCCCO2)[nH]c2nc(Nc3c4CCCc4cc4CCCc34)nn12

InChI Key InChIKey=YDJJCVMHTGJPTQ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50601246   

LigandPNGBDBM50601246(CHEMBL5185500)
Affinity DataIC50: 130nMAssay Description:Inhibition of NLRP3 inflammasome in LPS-pretreated PBMC (unknown origin) assessed as reduction in IL-1beta release pretreated for 30 mins followed by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
LigandPNGBDBM50601246(CHEMBL5185500)
Affinity DataIC50: 8.90E+3nMAssay Description:Inhibition of NLRP3 inflammasome in LPS-pretreated human whole blood assessed as reduction in IL-1beta release pretreated for 30 mins followed by ATP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
LigandPNGBDBM50601246(CHEMBL5185500)
Affinity DataIC50: 190nMAssay Description:Inhibition of NLRP3 inflammasome in LPS-pretreated human THP1-ASC-GFP cells assessed as reduction in speck positive cells measured after 30 mins in p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed