BDBM50601067 CHEMBL5208088::US11702418, Example 6-4
SMILES Cc1c(cccc1C(F)(F)F)[C@@H](C)Nc2c3cc(ccc3c(nn2)C)N4CCNCC4
InChI Key InChIKey=MJSKXOIIHARCLW-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 3 hits for monomerid = 50601067
Affinity DataIC50: 47nMAssay Description:Table 24: This Example illustrates that exemplary compounds of the present invention prevent KRas-mediated GTP nucleotide exchange mediated by SOS1 t...More data for this Ligand-Target Pair
Affinity DataKi: 0.110nMAssay Description:Table 22: This Example illustrates that exemplary compounds of the present invention bind to SOS1 and prevent a labeled tracer ligand from occupying ...More data for this Ligand-Target Pair
Affinity DataKi: 0.330nMAssay Description:Binding affinity to N-terminal his-TEV-Avi-tagged human recombinant SOS1 expressed in Escherichia coli assessed as inhibition constant incubated for ...More data for this Ligand-Target Pair