BDBM50601064 CHEMBL5174300::US11702418, Example 1-14

SMILES CNCc1ccccc1-c1csc(c1)[C@@H](C)Nc1nncc2cc(OC)c(OC)cc12

InChI Key InChIKey=VAGASTYGBBQOMO-UHFFFAOYSA-N

Data  1 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50601064   

TargetSon of sevenless homolog 1 [564-1049]()
Mirati Therapeutics

US Patent
LigandPNGBDBM50601064(CHEMBL5174300 | US11702418, Example 1-14)
Affinity DataIC50: 25nMAssay Description:Table 21: This Example illustrates that exemplary compounds of the present invention bind to SOS1 and prevent a labeled tracer ligand from occupying ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2023
Entry Details
Go to US Patent

TargetSon of sevenless homolog 1 [564-1049]()
Mirati Therapeutics

US Patent
LigandPNGBDBM50601064(CHEMBL5174300 | US11702418, Example 1-14)
Affinity DataIC50: 165nMAssay Description:Table 24: This Example illustrates that exemplary compounds of the present invention prevent KRas-mediated GTP nucleotide exchange mediated by SOS1 t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2023
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor(Human)
Mirati Therapeutics

Curated by ChEMBL
LigandPNGBDBM50601064(CHEMBL5174300 | US11702418, Example 1-14)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human EGFR in presence of ATP by radiometric HotSpot assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetSon of sevenless homolog 1(Human)
Mirati Therapeutics

Curated by ChEMBL
LigandPNGBDBM50601064(CHEMBL5174300 | US11702418, Example 1-14)
Affinity DataKi:  3.90nMAssay Description:Binding affinity to N-terminal his-TEV-Avi-tagged human recombinant SOS1 expressed in Escherichia coli assessed as inhibition constant incubated for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed