BDBM50600761 CHEMBL5197086::US20240043470, Compound 1-51

SMILES CC(=O)N[C@H]1Cc2cccc(Oc3cccc(C[C@H](NC(=O)[C@H](CCc4ccccc4)NC1=O)C(=O)NCc1ccc(C)cc1)c3)c2

InChI Key InChIKey=DPUNWDMMVCXQFI-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50600761   

TargetProteasome subunit beta type-5(Human)
Weill Cornell Medicine

Curated by ChEMBL
LigandPNGBDBM50600761(CHEMBL5197086 | US20240043470, Compound 1-51)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human 20S constitutive proteasome beta-5c subunit using Suc-LLVY-AMC as substrate measured after 1.2 hrs in presence of SDSMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetProteasome subunit beta type-8(Human)
Weill Cornell Medicine

Curated by ChEMBL
LigandPNGBDBM50600761(CHEMBL5197086 | US20240043470, Compound 1-51)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human 20S immunoproteasome beta-5i subunit using Ac-ANW-AMC as substrate measured after 1.2 hrs in presence of SDSMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetProteasome subunit beta type-5(Human)
Weill Cornell Medicine

Curated by ChEMBL
LigandPNGBDBM50600761(CHEMBL5197086 | US20240043470, Compound 1-51)
Affinity DataIC50: 6.70E+3nMAssay Description:Experiments to determine IC50 values against β5i and β5c for compounds were carried out in 96-well plates. In brief, 1 μL of compound ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2024
Entry Details
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