BDBM50600318 CHEMBL5179104

SMILES COc1cc(ccc1Nc1ncc(Cl)c(Nc2ccccc2P(C)(C)=O)n1)C1CCC2(CC1)CCN(C)CC2

InChI Key InChIKey=PVDMLWGETVVQNO-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50600318   

TargetALK tyrosine kinase receptor(Human)
Wuxi Apptec

Curated by ChEMBL
LigandPNGBDBM50600318(CHEMBL5179104)
Affinity DataIC50: 6.5nMAssay Description:Inhibition of ALK C1156Y mutant (unknown origin) using biotinylated substrate incubated for 1 hr in the presence of ATP at Km concentration by HTRF a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetALK tyrosine kinase receptor(Human)
Wuxi Apptec

Curated by ChEMBL
LigandPNGBDBM50600318(CHEMBL5179104)
Affinity DataIC50: 4.20nMAssay Description:Inhibition of ALK L1196M mutant (unknown origin) using biotinylated substrate incubated for 1 hr in the presence of ATP at Km concentration by HTRF a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetALK tyrosine kinase receptor(Human)
Wuxi Apptec

Curated by ChEMBL
LigandPNGBDBM50600318(CHEMBL5179104)
Affinity DataIC50: 3.80nMAssay Description:Inhibition of wild type ALK (unknown origin) using biotinylated substrate incubated for 1 hr in the presence of ATP at Km concentration by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed