BDBM50600317 IRUPLINALKIB::Iruplinalkib

SMILES COc1cc(ccc1Nc1ncc(Cl)c(Nc2ccccc2P(C)(C)=O)n1)N1CCC2(CCN(C)CC2)CC1

InChI Key InChIKey=ZPCCNHQDFZCULN-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50600317   

TargetALK tyrosine kinase receptor(Human)
Wuxi Apptec

Curated by ChEMBL
LigandPNGBDBM50600317(IRUPLINALKIB | Iruplinalkib)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of ALK C1156Y mutant (unknown origin) using biotinylated substrate incubated for 1 hr in the presence of ATP at Km concentration by HTRF a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetALK tyrosine kinase receptor(Human)
Wuxi Apptec

Curated by ChEMBL
LigandPNGBDBM50600317(IRUPLINALKIB | Iruplinalkib)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of ALK L1196M mutant (unknown origin) using biotinylated substrate incubated for 1 hr in the presence of ATP at Km concentration by HTRF a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetALK tyrosine kinase receptor(Human)
Wuxi Apptec

Curated by ChEMBL
LigandPNGBDBM50600317(IRUPLINALKIB | Iruplinalkib)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of wild type ALK (unknown origin) using biotinylated substrate incubated for 1 hr in the presence of ATP at Km concentration by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Wuxi Apptec

Curated by ChEMBL
LigandPNGBDBM50600317(IRUPLINALKIB | Iruplinalkib)
Affinity DataIC50: 35nMAssay Description:Inhibition of wild type EGFR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed