BDBM50600300 CHEMBL5184238

SMILES COc1ccc(cc1)C1(CCCCC1)C(=O)N1CCC[C@@H]1C(=O)Nc1cccc2[nH]ncc12

InChI Key InChIKey=XTWOKGWVMFHYAN-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50600300   

TargetHistone acetyltransferase p300(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50600300(CHEMBL5184238)
Affinity DataIC50: 170nMAssay Description:Inhibition of N-terminal His tagged human EP300 (1159-1666 residues) expressed in Escherichia coli BL21 (DE3) using biotinylated H4 (1 to 25)-GSGSK p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetHistone acetyltransferase p300(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50600300(CHEMBL5184238)
Affinity DataIC50: 420nMAssay Description:Inhibition of EP300 in human LK2 cells assessed as reduction in intracellular histone H3 acetylation at lysine 27 residue incubated for 3 hrs by chem...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetHistone acetyltransferase p300(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50600300(CHEMBL5184238)
Affinity DataIC50: 167nMAssay Description:Inhibition of recombinant human full length EP300 assessed as inhibition of H4 peptide acetylation using biotinylated H4 peptide as substrate in pres...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetHistone acetyltransferase p300(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50600300(CHEMBL5184238)
Affinity DataIC50: 420nMAssay Description:Inhibition of EP300 in human LK2 cells assessed as reduction in intracellular H3K27 acetylation incubated for 3 hrs by chemiluminescence based ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed