BDBM50600296 CHEMBL5177811

SMILES COc1ccc(cc1)C1(CCCCC1)C(=O)N1CCOCC(Cc2cccc3[nH]ncc23)C1

InChI Key InChIKey=UJFBHTPXHIYRGU-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50600296   

TargetHistone acetyltransferase p300(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50600296(CHEMBL5177811)
Affinity DataIC50: 140nMAssay Description:Inhibition of N-terminal His tagged human EP300 (1159-1666 residues) expressed in Escherichia coli BL21 (DE3) using biotinylated H4 (1 to 25)-GSGSK p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetHistone acetyltransferase p300(Human)
Daiichi Sankyo

Curated by ChEMBL
LigandPNGBDBM50600296(CHEMBL5177811)
Affinity DataIC50: 610nMAssay Description:Inhibition of EP300 in human LK2 cells assessed as reduction in intracellular histone H3 acetylation at lysine 27 residue incubated for 3 hrs by chem...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed