BDBM50600161 CHEMBL5194482

SMILES CN1CCN(CC1)c1ccc(Nc2ncc3ccc(=O)n(Cc4cccc(NC(=O)C=C)c4)c3n2)cc1

InChI Key InChIKey=IWZBRDQHSFANGJ-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50600161   

TargetTyrosine-protein kinase JAK3(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50600161(CHEMBL5194482)
Affinity DataIC50: 2nMAssay Description:Covalent inhibition of recombinant recombinant human GST-tagged JAK3(781 to 1124 residues) expressed in baculovirus expression system incubated for 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50600161(CHEMBL5194482)
Affinity DataIC50: 2.43E+3nMAssay Description:Inhibition of JAK1 (unknown origin) incubated for 1 hr in the presence of ATP by FRET based Z'-LYTE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50600161(CHEMBL5194482)
Affinity DataIC50: 1.13E+3nMAssay Description:Inhibition of JAK2 (unknown origin) incubated for 1 hr in the presence of ATP by FRET based Z'-LYTE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50600161(CHEMBL5194482)
Affinity DataIC50: 8.88E+3nMAssay Description:Inhibition of TYK2 (unknown origin) incubated for 1 hr in the presence of ATP by FRET based Z'-LYTE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetTyrosine-protein kinase BTK(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50600161(CHEMBL5194482)
Affinity DataIC50: 16nMAssay Description:Inhibition of BTK (unknown origin) incubated for 1 hr in the presence of ATP by FRET based Z'-LYTE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50600161(CHEMBL5194482)
Affinity DataIC50: 261nMAssay Description:Inhibition of wild type EGFR (unknown origin) incubated for 1 hr in the presence of ATP by FRET based Z'-LYTE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50600161(CHEMBL5194482)
Affinity DataIC50: 216nMAssay Description:Inhibition of EGFR T790M mutant (unknown origin) incubated for 1 hr in the presence of ATP by FRET based Z'-LYTE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed