BDBM50600122 CHEMBL5187181::US20240336588, Compound 47

SMILES Oc1cc(O)c2C[C@@H](OC(=O)c3cc(O)c(O)c(O)c3F)[C@@H](Oc2c1)c1cc(O)c(O)c(O)c1F

InChI Key InChIKey=XIHYCFUEGQYDSC-UHFFFAOYSA-N

Data  2 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50600122   

TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Human)
Avanti Biosciences

Curated by ChEMBL

LigandBDBM50600122(CHEMBL5187181 | US20240336588, Compound 47)Copy SMILESCopy InChI

Affinity DataIC50: 54nMAssay Description:Inhibition of DYRK1A (unknown origin) using HT-497 as substrate preincubated with compound followed by substrate addition and measured after 30 mins ...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
6/23/2023
Entry Details
Copy Entry DOIPubMed
Copy Rxn URL

TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Human)
Avanti Biosciences

Curated by ChEMBL

LigandBDBM50600122(CHEMBL5187181 | US20240336588, Compound 47)Copy SMILESCopy InChI

Affinity DataIC50: 100nMAssay Description:DYRK1A assay. Substrate, HT-PRD (Proline rich domain, residues 746-864 of dynamin 1a, prepared as N-terminal tagged 6×His fusion protein), was dilute...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
2/10/2025
Entry Details
Copy Entry DOIGo to US Patent

Copy Rxn URL