BDBM50599594 CHEMBL5171272

SMILES CNC(=O)c1cc(Nc2ccccc2)cc(c1)-c1ccnc(NC(=O)C2CCOCC2)c1

InChI Key InChIKey=VBODBJMAVPEPIF-UHFFFAOYSA-N

Data  11 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50599594   

TargetPhosphatidylinositol 4-phosphate 5-kinase type-1 alpha(Human)
Astrazeneca

Curated by ChEMBL

LigandBDBM50599594(CHEMBL5171272)Copy SMILESCopy InChI

Affinity DataIC50: 95nMAssay Description:Inhibition of PIP5Kalpha (unknown origin)More data for this Ligand-Target Pair

Target InfoKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
6/23/2023
Entry Details
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TargetPhosphatidylinositol 4-phosphate 5-kinase type-1 beta(Human)
Astrazeneca

Curated by ChEMBL

LigandBDBM50599594(CHEMBL5171272)Copy SMILESCopy InChI

Affinity DataIC50: 13nMAssay Description:Inhibition of PIP5Kbeta (unknown origin)More data for this Ligand-Target Pair

Target InfoUniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
6/23/2023
Entry Details
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TargetPhosphatidylinositol 4-phosphate 5-kinase type-1 gamma(Human)
Astrazeneca

Curated by ChEMBL

LigandBDBM50599594(CHEMBL5171272)Copy SMILESCopy InChI

Affinity DataIC50: 9.5nMAssay Description:Inhibition of PIP5Kgamma (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
6/23/2023
Entry Details
Copy Entry DOIPubMed
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TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Astrazeneca

Curated by ChEMBL

LigandBDBM50599594(CHEMBL5171272)Copy SMILESCopy InChI

Affinity DataIC50: 3.90E+4nMAssay Description:Inhibition of PI3Kalpha (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
6/23/2023
Entry Details
Copy Entry DOIPubMed
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TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Human)
Astrazeneca

Curated by ChEMBL

LigandBDBM50599594(CHEMBL5171272)Copy SMILESCopy InChI

Affinity DataIC50: 4.20E+4nMAssay Description:Inhibition of PI3Kbeta (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
6/23/2023
Entry Details
Copy Entry DOIPubMed
Copy Rxn URL

TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Human)
Astrazeneca

Curated by ChEMBL

LigandBDBM50599594(CHEMBL5171272)Copy SMILESCopy InChI

Affinity DataIC50: 2.20E+4nMAssay Description:Inhibition of PI3Kgamma (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
6/23/2023
Entry Details
Copy Entry DOIPubMed
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TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
Astrazeneca

Curated by ChEMBL

LigandBDBM50599594(CHEMBL5171272)Copy SMILESCopy InChI

Affinity DataIC50: 1.60E+4nMAssay Description:Inhibition of PI3Kdelta (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
6/23/2023
Entry Details
Copy Entry DOIPubMed
Copy Rxn URL

TargetPhosphatidylinositol 4-kinase alpha(Human)
Astrazeneca

Curated by ChEMBL

LigandBDBM50599594(CHEMBL5171272)Copy SMILESCopy InChI

Affinity DataIC50: 1.30E+4nMAssay Description:Inhibition of PI4Kalpha (unknown origin)More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
6/23/2023
Entry Details
Copy Entry DOIPubMed
Copy Rxn URL

TargetPhosphatidylinositol 4-kinase beta(Human)
Astrazeneca

Curated by ChEMBL

LigandBDBM50599594(CHEMBL5171272)Copy SMILESCopy InChI

Affinity DataIC50: 6.50E+3nMAssay Description:Inhibition of PI4Kbeta (unknown origin)More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
6/23/2023
Entry Details
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TargetPlatelet-derived growth factor receptor beta(Human)
Astrazeneca

Curated by ChEMBL

LigandBDBM50599594(CHEMBL5171272)Copy SMILESCopy InChI

Affinity DataIC50: 5.90E+3nMAssay Description:Inhibition of PDGFRbeta (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
6/23/2023
Entry Details
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Target[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial(Human)
Astrazeneca

Curated by ChEMBL

LigandBDBM50599594(CHEMBL5171272)Copy SMILESCopy InChI

Affinity DataIC50: 4.40E+3nMAssay Description:Inhibition of PDK1 in human BT-474 cells assessed as reduction in AKT phosphorylation at T308 residue incubated for 2 hrsMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
6/23/2023
Entry Details
Copy Entry DOIPubMed
Copy Rxn URL