BDBM50599013 CHEMBL5199622::US20230322715, Compound TR-FTO-44

SMILES Fc1ccc2c(CNCC3(COC3)N3CCCC3)c[nH]c2c1

InChI Key InChIKey=MLMVCQYIAGOODR-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50599013   

TargetRNA demethylase ALKBH5(Human)
University of California San Diego

Curated by ChEMBL
LigandPNGBDBM50599013(CHEMBL5199622 | US20230322715, Compound TR-FTO-44)
Affinity DataIC50: 2.30E+3nMAssay Description:Inhibition of ALKBH5 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Human)
University of California San Diego

Curated by ChEMBL
LigandPNGBDBM50599013(CHEMBL5199622 | US20230322715, Compound TR-FTO-44)
Affinity DataIC50: 830nMAssay Description:Inhibition of recombinant FTO (unknown origin) using m6A Broccoli as substrate incubated for 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Human)
University of California San Diego

Curated by ChEMBL
LigandPNGBDBM50599013(CHEMBL5199622 | US20230322715, Compound TR-FTO-44)
Affinity DataIC50: 830nMAssay Description:The in vitro inhibition assay method was adapted from Svenson and Jaffrey, 2016. All reactions were performed in a 96-well plate with 200 μL ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2023
Entry Details
Go to US Patent

TargetRNA demethylase ALKBH5(Human)
University of California San Diego

Curated by ChEMBL
LigandPNGBDBM50599013(CHEMBL5199622 | US20230322715, Compound TR-FTO-44)
Affinity DataIC50: 2.30E+3nMAssay Description:The in vitro inhibition assay method was adapted from Svenson and Jaffrey, 2016. All reactions were performed in a 96-well plate with 200 μL ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2023
Entry Details
Go to US Patent

TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Human)
University of California San Diego

Curated by ChEMBL
LigandPNGBDBM50599013(CHEMBL5199622 | US20230322715, Compound TR-FTO-44)
Affinity DataIC50: 440nMAssay Description:The in vitro inhibition assay method was adapted from Svenson and Jaffrey, 2016. All reactions were performed in a 96-well plate with 200 μL ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2023
Entry Details
Go to US Patent

TargetRNA demethylase ALKBH5(Human)
University of California San Diego

Curated by ChEMBL
LigandPNGBDBM50599013(CHEMBL5199622 | US20230322715, Compound TR-FTO-44)
Affinity DataIC50: 1.72E+4nMAssay Description:The in vitro inhibition assay method was adapted from Svenson and Jaffrey, 2016. All reactions were performed in a 96-well plate with 200 μL ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2023
Entry Details
Go to US Patent