BDBM50598855 CHEMBL5190904::US20240207300, Compound 116

SMILES Cc1ccc(O)c(C)c1-n1c(N)c(C(N)=O)c2cc(cnc12)C1CC1

InChI Key InChIKey=ILXVHUCIJXHLFY-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50598855   

LigandPNGBDBM50598855(CHEMBL5190904 | US20240207300, Compound 116)
Affinity DataIC50: 5nMAssay Description:Inhibition of N-terminal recombinant PKMYT1 (76 to 362 residues) in CCNE1 amplified human FU-OV-1 cells assessed as phosphorylation of CDK1 at Thr14 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
LigandPNGBDBM50598855(CHEMBL5190904 | US20240207300, Compound 116)
Affinity DataIC50: 3nMAssay Description:Inhibition of full length Nano-luc fused PKMYT1 in human HEK-293T cells incubated for 2 hrs by cell based NanoBRET target engagement assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetMyelin transcription factor 1(Human)
Repare Therapeutics

US Patent
LigandPNGBDBM50598855(CHEMBL5190904 | US20240207300, Compound 116)
Affinity DataIC50: 10nMAssay Description:Detection of Myt1 kinase activity utilized a recombinant human Myt1 kinase assay measuring the hydrolysis of ATP using a commercially available ADP-G...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2024
Entry Details
Go to US Patent