BDBM50598854 CHEMBL5174684::US20240207300, Compound 135

SMILES Cc1cnc2n(c(N)c(C(N)=O)c2c1)-c1c(C)ccc(O)c1C

InChI Key InChIKey=ULDZGHWDQNMQNE-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50598854   

LigandPNGBDBM50598854(CHEMBL5174684 | US20240207300, Compound 135)
Affinity DataIC50: 24nMAssay Description:Inhibition of N-terminal recombinant PKMYT1 (76 to 362 residues) in CCNE1 amplified human FU-OV-1 cells assessed as phosphorylation of CDK1 at Thr14 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
LigandPNGBDBM50598854(CHEMBL5174684 | US20240207300, Compound 135)
Affinity DataIC50: 1nMAssay Description:Inhibition of full length Nano-luc fused PKMYT1 in human HEK-293T cells incubated for 2 hrs by cell based NanoBRET target engagement assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetMyelin transcription factor 1(Human)
Repare Therapeutics

US Patent
LigandPNGBDBM50598854(CHEMBL5174684 | US20240207300, Compound 135)
Affinity DataIC50: 10nMAssay Description:Detection of Myt1 kinase activity utilized a recombinant human Myt1 kinase assay measuring the hydrolysis of ATP using a commercially available ADP-G...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2024
Entry Details
Go to US Patent

TargetMyelin transcription factor 1(Human)
Repare Therapeutics

US Patent
LigandPNGBDBM50598854(CHEMBL5174684 | US20240207300, Compound 135)
Affinity DataIC50: 10nMAssay Description:Detection of Myt1 kinase activity utilized a recombinant human Myt1 kinase assay measuring the hydrolysis of ATP using a commercially available ADP-G...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2024
Entry Details
Go to US Patent