BDBM50598704 CHEMBL5203904::US20230348487, Example LS 3-96

SMILES [H][C@]12OC[C@H](Oc3nc(Nc4ccc(N5CCC(CC5)N5CCN(C)CC5)c(Cl)c4)ncc3Cl)[C@@]1([H])OC[C@H]2O

InChI Key InChIKey=APDFRGIBBFMHRS-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50598704   

TargetTyrosine-protein kinase JAK1(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50598704(CHEMBL5203904 | US20230348487, Example LS 3-96)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of GST-tagged recombinant human JAK1 (866 to 1154 residues) expressed in baculovirus infection system by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50598704(CHEMBL5203904 | US20230348487, Example LS 3-96)
Affinity DataIC50: 8.16E+3nMAssay Description:Inhibition of GST tagged recombinant human JAK2 expressed in baculovirus infection system by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50598704(CHEMBL5203904 | US20230348487, Example LS 3-96)
Affinity DataIC50: 268nMAssay Description:Inhibition of GST tagged recombinant human JAK3 expressed in baculovirus infection system by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50598704(CHEMBL5203904 | US20230348487, Example LS 3-96)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human TYK2 by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50598704(CHEMBL5203904 | US20230348487, Example LS 3-96)
Affinity DataIC50: 1.00E+4nMAssay Description:Test method: Firstly, test compounds were prepared into 10 mM stock solution with DMSO, and continuously diluted into 10 concentrations at a 3-fold g...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2023
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK2(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50598704(CHEMBL5203904 | US20230348487, Example LS 3-96)
Affinity DataIC50: 8.16E+3nMAssay Description:Test method: Firstly, test compounds were prepared into 10 mM stock solution with DMSO, and continuously diluted into 10 concentrations at a 3-fold g...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2023
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK3(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50598704(CHEMBL5203904 | US20230348487, Example LS 3-96)
Affinity DataIC50: 268nMAssay Description:Test method: Firstly, test compounds were prepared into 10 mM stock solution with DMSO, and continuously diluted into 10 concentrations at a 3-fold g...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2023
Entry Details
Go to US Patent

TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50598704(CHEMBL5203904 | US20230348487, Example LS 3-96)
Affinity DataIC50: 1.00E+4nMAssay Description:Test method: Firstly, test compounds were prepared into 10 mM stock solution with DMSO, and continuously diluted into 10 concentrations at a 3-fold g...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2023
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK3(Human)
Jinan University

Curated by ChEMBL
LigandPNGBDBM50598704(CHEMBL5203904 | US20230348487, Example LS 3-96)
Affinity DataIC50: 1.00E+4nMAssay Description:Test method: Firstly, test compounds were prepared into 10 mM stock solution with DMSO, and continuously diluted into 10 concentrations at a 3-fold g...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2023
Entry Details
Go to US Patent