BDBM50598500 CHEMBL5196939::US20240368170, Compound 25

SMILES Cc1ccncc1-c1cc(N)c2nnc(NC(=O)C3CC3)cc2c1

InChI Key InChIKey=UKGQEXUWUBQQTP-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50598500   

TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50598500(CHEMBL5196939 | US20240368170, Compound 25)
Affinity DataKi:  1.90nMAssay Description:Inhibition of HPK1 (1 to 346 residues) (unknown origin) assessed as inhibition constant by Lanthascreen binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50598500(CHEMBL5196939 | US20240368170, Compound 25)
Affinity DataKi:  1.90nMAssay Description:For the binding assay, 4 μL 2×HPK1 and Eu-anti-GST antibody were added to each well of the assay plate using a Multidrop reagent dispenser. The solut...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/14/2025
Entry Details
Go to US Patent