BDBM50598211 CHEMBL5173327

SMILES CCCOc1ccc(Cl)cc1CN(CCc1ccc(cc1)S(=O)(=O)NCC#C)C(=O)c1ccc(F)cc1

InChI Key InChIKey=XUDDOZDERLRZIJ-UHFFFAOYSA-N

Data  4 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50598211   

TargetNACHT, LRR and PYD domains-containing protein 3(Mouse)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50598211(CHEMBL5173327)
Affinity DataIC50: 120nMAssay Description:Inhibition of NLRP3 inflammasome in LPS-primed mouse J774.A1 cells assessed as reduction in IL-1beta secretion preincubated for 30 mins followed by A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetNLR family CARD domain-containing protein 4(Mouse)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50598211(CHEMBL5173327)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of NLRC4 inflammasome in LPS-primed mouse J774.A1 cells assessed as reduction in IL-1beta secretion preincubated for 1 hr followed by flag...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetInterferon-inducible protein AIM2(Mouse)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50598211(CHEMBL5173327)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of AIM2 inflammasome in LPS-primed mouse J774.A1 cells assessed as reduction in IL-1beta secretion preincubated for 1 hr followed by poly(...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Mouse)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50598211(CHEMBL5173327)
Affinity DataIC50: 910nMAssay Description:Inhibition of NLRP3 inflammasome in LPS-primed mouse BMDM cells assessed as reduction in IL-1beta secretion preincubated for 30 mins followed by ATP ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Human)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50598211(CHEMBL5173327)
Affinity DataKd:  84nMAssay Description:Binding affinity to human recombinant full length NLRP3 transfected in HEK293F cells assessed as dissociation constant incubated for 40 mins by micro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed