BDBM50598078 CHEMBL5207141

SMILES CCN1C(=O)COc2c(CN3CCN(CC3)C(C)=O)cc(Nc3ncc(F)c(n3)-c3ccc(F)cc3OC)cc12

InChI Key InChIKey=YKSDGHNGKNMUGI-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50598078   

TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50598078(CHEMBL5207141)
Affinity DataIC50: 2.60nMAssay Description:Inhibition of CDK9/Cyclin T1 (unknown origin) preincubated for 10 mins followed by ATP and CTD3 addition and measured after 30 mins by mobility shift...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50598078(CHEMBL5207141)
Affinity DataIC50: 173nMAssay Description:Inhibition of CDK1/cyclin B1 (unknown origin) preincubated for 10 mins followed by ATP and substrate addition and measured after 60 mins by HTRF anal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50598078(CHEMBL5207141)
Affinity DataIC50: 159nMAssay Description:Inhibition of CDK4/cyclin D3 (unknown origin) preincubated for 10 mins followed by ATP and substrate addition and measured after 60 mins by HTRF anal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetCyclin-H/Cyclin-dependent kinase 7(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50598078(CHEMBL5207141)
Affinity DataIC50: 58nMAssay Description:Inhibition of CDK7/cyclin H (unknown origin) preincubated for 10 mins followed by ATP and substrate addition and measured after 60 mins by HTRF analy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetCyclin-C(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50598078(CHEMBL5207141)
Affinity DataIC50: 44nMAssay Description:Inhibition of CDK8/cyclin C (unknown origin) preincubated for 10 mins followed by ATP and substrate addition and measured after 60 mins by HTRF analy...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetCyclin-dependent kinase 12(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50598078(CHEMBL5207141)
Affinity DataIC50: 42nMAssay Description:Inhibition of CDK12/cyclin K (unknown origin) preincubated for 10 mins followed by ATP and substrate addition and measured after 60 mins by HTRF anal...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed