BDBM50597348 CHEMBL5177284

SMILES Cc1ccc(-c2cn([C@@H]3CC[C@H](N)CC3)c3ncnc(N)c23)c(F)c1

InChI Key InChIKey=DSKYHEJWWIBREA-UHFFFAOYSA-N

Data  7 IC50  5 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50597348   

TargetEpithelial discoidin domain-containing receptor 1(Human)
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50597348(CHEMBL5177284)
Affinity DataIC50: 15nMAssay Description:Inhibition of human DDR1 by kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50597348(CHEMBL5177284)
Affinity DataIC50: 56nMAssay Description:Inhibition of human c-SRC by kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetSerine/threonine-protein kinase SIK1(Human)
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50597348(CHEMBL5177284)
Affinity DataIC50: 89nMAssay Description:Inhibition of human SIK by kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50597348(CHEMBL5177284)
Affinity DataIC50: 862nMAssay Description:Inhibition of human PDGFRbeta by kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50597348(CHEMBL5177284)
Affinity DataIC50: 1.51E+3nMAssay Description:Inhibition of human KIT by kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50597348(CHEMBL5177284)
Affinity DataIC50: 4.79E+3nMAssay Description:Inhibition of human FLT3 by kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50597348(CHEMBL5177284)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human RIPK1 by kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50597348(CHEMBL5177284)
Affinity DataKd:  0.280nMAssay Description:Binding affinity to human RIPK1 in human Jurkat cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 2(Human)
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50597348(CHEMBL5177284)
Affinity DataKd:  0.280nMAssay Description:Binding affinity to human RIPK2 in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 3(Human)
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50597348(CHEMBL5177284)
Affinity DataKd:  75nMAssay Description:Binding affinity to human RIPK3 in human Jurkat cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 4(Human)
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50597348(CHEMBL5177284)
Affinity DataKd:  2.30E+3nMAssay Description:Binding affinity to human RIPK4More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetDual serine/threonine and tyrosine protein kinase(Human)
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50597348(CHEMBL5177284)
Affinity DataKd:  670nMAssay Description:Binding affinity to human RIPK5More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed