BDBM50597196 CHEMBL5206031

SMILES Cc1ccc(NC(=O)N2CC[C@@H](CC(F)(F)F)C2)cc1-c1cnc(OCCN2CCN(CC2)c2ccc3C(=O)N(C4CCC(=O)NC4=O)C(=O)c3c2)c(c1)N1CCOCC1

InChI Key InChIKey=LRSPRURQRZURLJ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50597196   

TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Usona Institute

Curated by ChEMBL
LigandPNGBDBM50597196(CHEMBL5206031)
Affinity DataIC50: 10nMAssay Description:Inhibition of RAF in human WM3629 cells assessed as ERK phosphorylation at Thr202/Tyr204 residue incubated for 6 hrs by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Usona Institute

Curated by ChEMBL
LigandPNGBDBM50597196(CHEMBL5206031)
Affinity DataIC50: 100nMAssay Description:Inhibition of RAF in human A-375 cells assessed as ERK phosphorylation at Thr202/Tyr204 residue incubated for 6 hrs by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed