BDBM50597000 CHEMBL5199715::US20230303540, Example Ex-3.40

SMILES Clc1c(Nc2ncc3cc(Cl)c(cc3n2)N2CCC3(CCCO3)CC2)cnn1C12CC(C1)C2

InChI Key InChIKey=NCOOSSGSPRCOJC-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50597000   

TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM50597000(CHEMBL5199715 | US20230303540, Example Ex-3.40)
Affinity DataIC50: 0.174nMAssay Description:Inhibition of GST-tagged truncated human LRRK2 G2019S mutant using fluorescein labeled LRRKtide peptide as substrate preincubated for 15 mins followe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Human)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM50597000(CHEMBL5199715 | US20230303540, Example Ex-3.40)
Affinity DataIC50: 9.76nMAssay Description:The LRRK2 kinase activity reported herein as IC50 values was determined with LanthaScreen technology from Life Technologies Corporation (Carlsbad, CA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/6/2023
Entry Details
Go to US Patent