BDBM50596438 CHEMBL5188786

SMILES CC(C)CN1CCN(Cc2ccc(cc2C)-c2ncnc(N)c2OCCN(C)C(=O)C=C)C(=O)C1

InChI Key InChIKey=HGYLDYXQKAISMX-UHFFFAOYSA-N

Data  10 IC50  10 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 20 hits for monomerid = 50596438   

TargetTyrosine-protein kinase TXK(Human)
Biogen

Curated by ChEMBL
LigandPNGBDBM50596438(CHEMBL5188786)
Affinity DataKd:  6.50E+3nMAssay Description:Binding affinity to TXK (unknown origin) assessed as dissociation constant by KINOMEscan analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetTyrosine-protein kinase BTK(Human)
Biogen

Curated by ChEMBL
LigandPNGBDBM50596438(CHEMBL5188786)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of BTK-dependent human TMD8 cell proliferationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetTyrosine-protein kinase BTK(Human)
Biogen

Curated by ChEMBL
LigandPNGBDBM50596438(CHEMBL5188786)
Affinity DataIC50: 3.10nMAssay Description:Inhibition of BTK in human Ramos cells assessed as target occupancyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
LigandPNGBDBM50596438(CHEMBL5188786)
Affinity DataIC50: 6.00E+4nMAssay Description:Inhibition of hERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetCytochrome P450 3A4(Human)
Biogen

Curated by ChEMBL
LigandPNGBDBM50596438(CHEMBL5188786)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human CYP3A4More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetCytochrome P450 2D6(Human)
Biogen

Curated by ChEMBL
LigandPNGBDBM50596438(CHEMBL5188786)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetCytochrome P450 2C9(Human)
Biogen

Curated by ChEMBL
LigandPNGBDBM50596438(CHEMBL5188786)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human CYP2C9More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetCytochrome P450 2C8(Human)
Biogen

Curated by ChEMBL
LigandPNGBDBM50596438(CHEMBL5188786)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human CYP2C8More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetCytochrome P450 2B6(Human)
Biogen

Curated by ChEMBL
LigandPNGBDBM50596438(CHEMBL5188786)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human CYP2B6More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetCytochrome P450 1A2(Human)
Biogen

Curated by ChEMBL
LigandPNGBDBM50596438(CHEMBL5188786)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human CYP1A2More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetTyrosine-protein kinase BTK(Human)
Biogen

Curated by ChEMBL
LigandPNGBDBM50596438(CHEMBL5188786)
Affinity DataIC50: 0.220nMAssay Description:Inhibition of BTK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetTyrosine-protein kinase Tec(Human)
Biogen

Curated by ChEMBL
LigandPNGBDBM50596438(CHEMBL5188786)
Affinity DataKd:  240nMAssay Description:Binding affinity to TEC (unknown origin) assessed as dissociation constant by KINOMEscan analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Biogen

Curated by ChEMBL
LigandPNGBDBM50596438(CHEMBL5188786)
Affinity DataKd:  2.90E+3nMAssay Description:Binding affinity to JAK3 (unknown origin) assessed as dissociation constant by KINOMEscan analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetTyrosine-protein kinase ITK/TSK(Human)
Biogen

Curated by ChEMBL
LigandPNGBDBM50596438(CHEMBL5188786)
Affinity DataKd:  3.00E+4nMAssay Description:Binding affinity to ITK (unknown origin) assessed as dissociation constant by KINOMEscan analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Biogen

Curated by ChEMBL
LigandPNGBDBM50596438(CHEMBL5188786)
Affinity DataKd:  3.00E+4nMAssay Description:Binding affinity to EGFR (unknown origin) assessed as dissociation constant by KINOMEscan analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetTyrosine-protein kinase BTK(Human)
Biogen

Curated by ChEMBL
LigandPNGBDBM50596438(CHEMBL5188786)
Affinity DataKd:  0.910nMAssay Description:Binding affinity to BTK (unknown origin) assessed as dissociation constant by KINOMEscan analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetCytoplasmic tyrosine-protein kinase BMX(Human)
Biogen

Curated by ChEMBL
LigandPNGBDBM50596438(CHEMBL5188786)
Affinity DataKd:  790nMAssay Description:Binding affinity to BMX (unknown origin) assessed as dissociation constant by KINOMEscan analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetTyrosine-protein kinase Blk(Human)
Biogen

Curated by ChEMBL
LigandPNGBDBM50596438(CHEMBL5188786)
Affinity DataKd:  1.00E+4nMAssay Description:Binding affinity to BLK (unknown origin) assessed as dissociation constant by KINOMEscan analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetReceptor tyrosine-protein kinase erbB-4(Human)
Biogen

Curated by ChEMBL
LigandPNGBDBM50596438(CHEMBL5188786)
Affinity DataKd:  890nMAssay Description:Binding affinity to ERBB4 (unknown origin) assessed as dissociation constant by KINOMEscan analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Biogen

Curated by ChEMBL
LigandPNGBDBM50596438(CHEMBL5188786)
Affinity DataKd:  2.00E+4nMAssay Description:Binding affinity to ERBB2 (unknown origin) assessed as dissociation constant by KINOMEscan analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed