BDBM50596249 CHEMBL5170892

SMILES C[C@]1(CS(=O)(=O)[C@](C)(CF)C(=N)N1)c1nc(NC(=O)c2ccc(cn2)C#N)ccc1F

InChI Key InChIKey=GNWNOQLLBKOHTC-UHFFFAOYSA-N

Data  1 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50596249   

TargetBeta-secretase 1(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50596249(CHEMBL5170892)
Affinity DataIC50: 7nMAssay Description:Inhibition of BACE1 (unknown origin) expressed in HEK293 cells expressing human APP with Swedish and London familial AD mutationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
LigandPNGBDBM50596249(CHEMBL5170892)
Affinity DataIC50: 2.56E+4nMAssay Description:Displacement of MK499 from human ERG expressed in HEK membrane by radio ligand binding competition assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetBeta-secretase 1(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50596249(CHEMBL5170892)
Affinity DataKi:  3nMAssay Description:Inhibition of BACE1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed